A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations
Identifieur interne : 000611 ( Main/Corpus ); précédent : 000610; suivant : 000612A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations
Auteurs : Gabriella Santangelo ; Luigi Trojano ; Carmine Vitale ; Marta Ianniciello ; Marianna Amboni ; Dario Grossi ; Paolo BaroneSource :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
English descriptors
Abstract
The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21746
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ISTEX:FA06737FD15ADF911A8BCB008ADE6211952CF883Le document en format XML
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Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Gabriella Santangelo PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string></affiliations></json:item><json:item><name>Luigi Trojano MD</name><affiliations><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string><json:string>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, ItalyPaolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</json:string></affiliations></json:item><json:item><name>Carmine Vitale MD, PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Marta Ianniciello MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string></affiliations></json:item><json:item><name>Marianna Amboni MD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Dario Grossi MD</name><affiliations><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD, PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, ItalyPaolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hallucinations</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognitive function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frontal dysfunction</value></json:item></subject><articleId><json:string>MDS21746</json:string></articleId><language><json:string>eng</json:string></language><abstract>The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society</abstract><qualityIndicators><score>7.244</score><pdfVersion>1.3</pdfVersion><pdfPageSize>594 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1521</abstractCharCount><pdfWordCount>4748</pdfWordCount><pdfCharCount>32419</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>208</abstractWordCount></qualityIndicators><title>A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title><genre><json:string>article</json:string></genre><host><volume>22</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>8</total><last>2425</last><first>2418</first></pages><issn><json:string>0885-3185</json:string></issn><issue>16</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1002/mds.21746</json:string></doi><id>FA06737FD15ADF911A8BCB008ADE6211952CF883</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/FA06737FD15ADF911A8BCB008ADE6211952CF883/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/FA06737FD15ADF911A8BCB008ADE6211952CF883/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FA06737FD15ADF911A8BCB008ADE6211952CF883/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2007</date></publicationStmt><notesStmt><note>Ministero della Salute, Ricerca Finalizzata, art. 12 bis, D.L. - No. 229/99‐CONV 81;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title><author><persName><forename type="first">Gabriella</forename><surname>Santangelo</surname></persName><roleName type="degree">PhD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation></author><author><persName><forename type="first">Luigi</forename><surname>Trojano</surname></persName><roleName type="degree">MD</roleName><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><affiliation>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, ItalyPaolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</affiliation></author><author><persName><forename type="first">Carmine</forename><surname>Vitale</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation></author><author><persName><forename type="first">Marta</forename><surname>Ianniciello</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation></author><author><persName><forename type="first">Marianna</forename><surname>Amboni</surname></persName><roleName type="degree">MD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation></author><author><persName><forename type="first">Dario</forename><surname>Grossi</surname></persName><roleName type="degree">MD</roleName><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. 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Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15"></date><biblScope unit="volume">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2418">2418</biblScope><biblScope unit="page" to="2425">2425</biblScope></imprint></monogr><idno type="istex">FA06737FD15ADF911A8BCB008ADE6211952CF883</idno><idno type="DOI">10.1002/mds.21746</idno><idno type="ArticleID">MDS21746</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>hallucinations</term></item><item><term>dementia</term></item><item><term>cognitive function</term></item><item><term>frontal dysfunction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-05-31">Received</change><change when="2007-08-23">Registration</change><change when="2007-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/FA06737FD15ADF911A8BCB008ADE6211952CF883/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="160"><doi origin="wiley" registered="yes">10.1002/mds.v22:16</doi><numberingGroup><numbering type="journalVolume" number="22">22</numbering><numbering type="journalIssue">16</numbering></numberingGroup><coverDate startDate="2007-12-15">15 December 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="180" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.21746</doi><idGroup><id type="unit" value="MDS21746"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2007 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2007-05-31"></event><event type="manuscriptRevised" date="2007-08-02"></event><event type="manuscriptAccepted" date="2007-08-23"></event><event type="firstOnline" date="2007-09-25"></event><event type="publishedOnlineFinalForm" date="2007-12-19"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2007-09-25"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.7 mode:FullText source:FullText result:FullText" date="2011-02-24"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">2418</numbering><numbering type="pageLast">2425</numbering></numberingGroup><correspondenceTo><lineatedText><line>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, Italy</line><line>Paolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</line></lineatedText></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS21746.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="61"></count><count type="wordTotal" number="5873"></count></countGroup><titleGroup><title type="main" xml:lang="en">A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title><title type="short" xml:lang="en">Cognitive State, PD, and Hallucinations</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Gabriella</givenNames><familyName>Santangelo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af2" corresponding="yes"><personName><givenNames>Luigi</givenNames><familyName>Trojano</familyName><degrees>MD</degrees></personName><contactDetails><email>luigi.trojano@unina2.it</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Carmine</givenNames><familyName>Vitale</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marta</givenNames><familyName>Ianniciello</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Marianna</givenNames><familyName>Amboni</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dario</givenNames><familyName>Grossi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>barone@unina.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">hallucinations</keyword><keyword xml:id="kwd3">dementia</keyword><keyword xml:id="kwd4">cognitive function</keyword><keyword xml:id="kwd5">frontal dysfunction</keyword></keywordGroup><fundingInfo><fundingAgency>Ministero della Salute, Ricerca Finalizzata, art. 12 bis, D.L.</fundingAgency><fundingNumber>229/99‐CONV 81</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, <i>P</i> = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, <i>P</i> = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, <i>P</i> = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognitive State, PD, and Hallucinations</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A neuropsychological longitudinal study in Parkinson's patients with and without hallucinations</title></titleInfo><name type="personal"><namePart type="given">Gabriella</namePart><namePart type="family">Santangelo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Trojano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><affiliation>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, ItalyPaolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmine</namePart><namePart type="family">Vitale</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marta</namePart><namePart type="family">Ianniciello</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marianna</namePart><namePart type="family">Amboni</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnostica e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dario</namePart><namePart type="family">Grossi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Luigi Trojano, Department of Psychology, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, ItalyPaolo Barone, Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-12-15</dateIssued><dateCaptured encoding="w3cdtf">2007-05-31</dateCaptured><dateValid encoding="w3cdtf">2007-08-23</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">61</extent><extent unit="words">5873</extent></physicalDescription><abstract lang="en">The aim of this work was to determine the progression of cognitive impairment in Parkinson's disease (PD) patients with or without hallucinations. Two years after the first assessment, 36 PD patients were re‐evaluated on standardized neuropsychological tests, including the Frontal Assessment Battery (FAB), and on rating scales for overall cognitive functioning, functional autonomy, behavioral disorders. Nine patients had hallucinations at baseline and endpoint assessments; 12 patients developed hallucinations during the follow‐up; and 15 patients were hallucination‐free throughout the study. Cognitive performance significantly declined in all three groups, but at endpoint assessment PD hallucinators scored significantly lower than nonhallucinators on phonological and semantic fluency tasks, immediate free recall and the go/no‐go FAB subtest; moreover, they showed more severe apathy than nonhallucinators. Reduced phonological fluency at baseline (odds ratio [OR], 13.5; 95% CI: 1.34–135.98, P = 0.027) was the only independent predictor of onset of hallucinations after 2 years, whereas hallucinations (OR, 10.1; 95% CI: 1.94–51.54, P = 0.006) and poor phonological fluency (OR, 6.1; 95% CI: 1.04–35.03, P = 0.045) independently predicted development of diffuse cognitive impairment. We concluded that reduced verbal fluency scores may predict the onset of hallucinations, while hallucinations and poor phonological fluency may predict development of dementia in PD patients. © 2007 Movement Disorder Society</abstract><note type="funding">Ministero della Salute, Ricerca Finalizzata, art. 12 bis, D.L. - No. 229/99‐CONV 81; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>hallucinations</topic><topic>dementia</topic><topic>cognitive function</topic><topic>frontal dysfunction</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2418</start><end>2425</end><total>8</total></extent></part></relatedItem><identifier type="istex">FA06737FD15ADF911A8BCB008ADE6211952CF883</identifier><identifier type="DOI">10.1002/mds.21746</identifier><identifier type="ArticleID">MDS21746</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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